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The Protective Effect of Salivae Miltiorrhizae Liguspyragine Hydrochloride and Glucose Injection on Isoproterenol-Induced Acute Myocardial Infarction in Rats

Ke Jian, Fu Wen-Juan, Pan Jian-Hao, Ma Xian-Peng, Bi Chang-Qiong, Wei Wei, Zhao Jing, Ge Fa-Huan, Nie Hong

Abstract


Salivae miltiorrhizae liguspyragine hydrochloride and glucose injection (SGI) are widely used in the clinical treatment of ischemic cerebrovascular diseases, but researches on the prevention and treatment of acute myocardial infarction (AMI) and other cardiovascular diseases are rarely reported. So, the purpose of this study is to evaluate preventive effect of SGI on AMI in rats and to explore its possible mechanism. In this study, isoproterenol-(ISO) induced AMI model in rats was established  Based on that, we studied the effect of SGI on ECG and cardiac function. We then investigated the effect of SGI on heart infarction area and heart histomorphology in AMI rats. Moreover, to explore the possible mechanisms, we tested the activities of myocardial enzymes in blood. Our study found that, SGI can improve the ECG of AMI rats and promote cardiac function to normal.

In addition, SGI can reduce the infarct size and inhibit myocardial injury. Moreover, SGI can reduce the content of serum CK, LDH, cTnI and BNP in AMI rats. Therefore, we confirmed that SGI possessed remarkably protective effects against ISO-induced AMI in rats.


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