Abstract
Background: The atypical cadherin Celsr3, which belongs to the core planar cell polarity group, orchestrates axonal guidance and network wiring. Previous work using regional inactivation of Celsr3 in forebrain showed that Celsr3 is widely involved in hippocampal maturation and connectivity. However, inactivation in the whole forebrain does not provide sufficient specificity to address the function of Celsr3 in detail.
Method: We studied the Celsr3|Emx1 mouse mutant model, in which Celsr3 is selectively inactivated in hippocampal projection neurons, but not in entorhinal cortex, basal ganglia and interneurons.
Result: In that mutant, the hippocampal cytoarchitecture was almost normal. Inactivation of Celsr3 in projection neurons perturbed intrinsic hippocampal wiring. Consistent with wiring defects, Celsr3|Emx1 mutant mice showed impaired learning and memory, and were less anxiety-prone than control mice.
Conclusion: Celsr3|Emx1 mutant mice provide a simple way to study the consequences of defective hippocampal wiring in absence of drastic structural anomalies.
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References
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