Journal of Pharmaceutical and Biomedical Sciences

Chlorhexidine: The Gold Standard Mouth Wash

Bharati Kolliyavar, Leena Shettar, Srinath Thakur

Abstract


Chlorhexidine (CHX) is used as the broad spectrum antiseptic since 1950. It is a widely used mouth wash because of its antiplaque and antigingivitis properties. Antibacterial activity of CHX is mainly by disrupting bacterial cell membrane, which causes leakage of cellular constituents and brings about cell death. Bactericidal and bacteriostatic activity depends on the dosage. This article discusses various clinical applications, properties and adverse effects of CHX.

Keywords


chlorhexidine, mouth wash, antiplaque agent

Full Text:

References


Balagopal S, Arjunkumar R. Chlorhexidine: the gold standard antiplaque agent. J Pharm Sci Res. 2013;5(12):270–4.

Gunsolley JC. A meta-analysis of six-month studies of antiplaque and antigingivitis agents. J Am Dent Assoc. 2006;137(12):1649–57.

Schroeder HE. Formation and Inhibition of Dental Calculus. Berlin: Hans Huber; 1969. pp. 145–72.

Löe H, Von der Fehr FR, Schiött CR. Inhibition of experimental caries by plaque prevention. The effect of chlorhexidine mouth rinses. Scand J Dent Res. 1972;80(1):1–9.

Corbet EF, Tam JO, Zee KY, Wong MC, Lo EC, Mombelli AW. Therapeutic effects of supervised Chlorhexidine mouth rinses on untreated gingivitis. Oral Dis. 1997;3:9–18.

Grenier D. Effect of chlorhexidine on the adherence properties of Porphyromonas gingivalis. J Clin Periodontol. 1996;23(2):140–2.

Vianna ME, Gomes BP, Berber VB, Zaia AA, Ferraz CC, de Souza- Filho FJ. In vitro evaluation of the antimicrobial activity of chlorhexidine and sodium hypochlorite. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004;97(1):79–84.

Bonesvoll P, Gjermo PA. Comparison between chlorhexidine and some quaternary ammonium compounds with regard to retention, salivary concentration and plaque inhibiting effect in human mouth after mouth rinses. Arch Oral Biol. 1978;23:289–94.

Addy M. Chlorhexidine compared with other locally delivered antimicrobials. A short review. J Clin Periodontol. 1986;13: 957–64.

Addy M, Renton-Harper P. The role of antiseptics in secondary prevention. In Lang NP, Karring T, Lindhe J (eds): Proceedings of the 2nd European Workshop on Periodontology, Chemicals in Periodontics. Berlin: Quintessence; 1996. pp. 152–73.

Elley BM. Antibacterial agents in the control of supragingival plaque—a review. Br Dent J. 1999;186:286–96.

Flötra L, Gjermo P, Rölla G, Waerhaug J. Side effects of chlorhexidine mouth washes. Scand J Dent Res. 1971;79:119–25.

Addy M. Evaluation of clinical trials of agents and procedures to prevent caries and periodontal disease, choosing products and recommending procedures. Int Dent J. 1995;45:185–96.

Watts A, Addy M. Tooth discolorations and staining: a review of the literature. Br Dent J. 2001;190:309–16.

Rosenberg M, Gelernter I, Barki M, Bar-Ness R. Day long reduction of oral malodor by two phase oil: water mouth rinse as compared to chlorhexidine and placebo rinses. J Periodontol. 1992;63:39–43.

Franco Neto CA, Parolo CC, Rösing CK, Maltz M. Comparative analysis of the effect of two chlorhexidine mouth rinses on plaque accumulation and gingival bleeding. Braz Oral Res. 2008;22(2):139–44.

Van Leewen MP, Slot DE, Vander Weijden GA. Essential oil compared to chlorhexidine with respect to plaque and parameters of gingival inflammation a systematic review. J Periodontol. 2011;82:174–94.

Papaionnou W, Vassilopoulos S, Vrotsos I, Margaritis V, Panis V. A comparison of a new alcohol-free 0.2% chlorhexidine oral rinse to an established 0.2% chlorhexidine rinse with alcohol for the control of dental plaque accumulation. Int J Dent Hyg. September 2015 [Epub ahead of print].

Van Strydonck DA, Slot DE, Van der Velden U, Van der Weijden F. Effect of a chlorhexidine mouth rinse on plaque, gingival inflammation and staining in gingivitis patients: a systematic review. J Clin Periodontol. 2012;39:1042–55.

Najafi MH, Taheri M, Mokhtari MR, Forouzanfar A, Farazi F, Mirzaee M, Ebrahiminik Z, Mehrara R. Comparative study of 0.2% and 0.12% digluconate chlorhexidine mouth rinses on the level of dental staining and gingival indices. Dent Research J (Isfahan). 2012;9:305–8.

Mirzadeh A, Rahmani S, Sirjani M, Mirzadeh A, Salahi S. A comparative

study on the effect of 0.2% chlorhexidine mouthwash and 0.2% chlorhexidine gel on gingivitis and plaque accumulation. Bull Env Pharmacol Life Sci. 2014;3:140–4.

Gunsolley JC. A meta-analysis of six-month studies of antiplaque and antigingivitis agents. J Am Dent Assoc. 2006;137(12):1649–57.

Solís C, Santos A, Nart J, Violant D. 0.2% chlorhexidine mouthwash with an antidiscoloration system versus 0.2% chlorhexidine mouthwash: a prospective clinical comparative study. J Periodontol. 2011;82(1):80–5.

Winkel EG, Roldán S, Van Winkelhoff AJ, Herrera D, Sanz M. Clinical effects of a new mouthrinse containing chlorhexidine, cetylpyridinium chloride and zinc-lactate on oral halitosis. A dual center, double-blind placebo-controlled study, J Clin Periodontol. 2003;30(4):300–6.

Van Steenberghe D, Avontroodt P, Peeters W, Pauwels M, Coucke W, Lijnen A, et al. Effect of different mouth rinses on morning breath. J Periodontol. 2001;72(9):1183–91.


Refbacks

  • There are currently no refbacks.


Copyright (c) 2016 Journal of Pharmaceutical and Biomedical Sciences

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.