Abstract
Objective To explore whether (2-[[(1,1-dimethylethyl)oxidoimino]-methyl]-3,5,6-trimethylpyrazine) (TBN) can protect retinal ganglion cells against acute high intraocular pressure injury.
Methods We used anterior chamber puncture to rapidly increase intraocular pressure to 70 mmHg in rats and continue to infuse for 60 min, resulting in retinal ischemia and death of retinal ganglion cells. After acute high intraocular pressure injury in rats, TBN (70 mg/kg body weight) or the equal volume of NS was administered by intraperitoneal for four consecutive days.
Results The results showed that the density of retinal ganglion cells was significantly decreased after acute high intraocular pressure injury, and TBN treatment significantly increased the survival rate of retinal ganglion cells.
Conclusion TBN may serve as a potential candidate to treat glaucoma.
Keywords
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