Journal of Pharmaceutical and Biomedical Sciences

Carcinoma Ovary Masquerading as Metastatic Hepatocellular Carcinoma—Case Report

Amitabh Kumar Upadhyay, Chandragouda Dodagoudar, Pankaj Goyal, Rakesh Gupta, Nidhi Gupta, Vijay Jagad

Abstract


Malignant tumors with hepatoid features resembling hepatocellular carcinoma have been described in different sites. These tumore are very rare and are found particularly in the stomach, ovary, pancreas, renal pelvis and urinary bladder. Hepatoid variant of carcinoma ovary was first of all reported by Isikura and Scully in 1987. Till date, with the best of our knowledge, only 21 patients with diagnosis of Hepatoid carcinoma of ovary have been reported. No case has been reported from India till date. This is a case of 56 years female presented to us with a complaint of abdominal distension, pain and weight loss of 2 months duration. Omental Biopsy was suggestive of hepatocellular carcinoma. On IHC, tumor cells were positive for HepPar 1, Glypican 3 and focal positivity for CK7 while negative for SALL4, PAX8, CK20 and TTF 1. She underwent interval cytoreductive surgery in January 2014. Final HPE report was hepatoid variant of carcinoma ovary.

901

Keywords


Hepatoid carcinoma ovary

Full Text:

References


Ishikura H, Scully RE. Hepatoid carcinoma of the ovary. A newly described tumor. Cancer. 1987;60:2775–2784.

Wang L, Zhong Y, Sun L, Zhou H, Chen W, Zhang X. Clinical and pathological features of hepatoid carcinoma of the ovary. World J Surg Oncol. 2013;11:29.

Llovet JM, Ricci S, Mazzaferro V, Hilgard P, Gane E, Blanc JF, et al; SHARP Investigators Study Group. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med. 2008;359:378–390.

Lazaro J, Rubio D, Repolles M, Capote L. Hepatoid carcinoma of the ovary and management. Acta Obstet Gynecol Scand. 2007;86:498–499.

Pandey M, Truica C. Hepatoid carcinoma of the ovary. J Clin Oncol. 2011;29:e446–e448.

Tochigi N, Kishimoto T, Supriatna Y, Nagai Y, Nikaido T, Ishikura H. Hepatoid carcinoma of the ovary: a report of three cases admixed with a common surface epithelial carcinoma. Int J Gynecol Pathol. 2003;22:266–271.

Zizi-Sermpetzoglou A, Petrakopoulou N, Nikolaidou ME, Tepelenis N, Savvaidou V, Vasilakaki T. Hepatoid carcinoma of the ovary. A case report and review of the literature. Eur J Gynaecol Oncol. 2009;30:341–343.

Nishida T, Sugiyama T, Kataoka A, Ushijima K, Ota S, Iwanaga S, et al. Ovarian hepatoid carcinoma without staining for alpha-fetoprotein in the primary site. Int J Gynecol Cancer. 1995;5:314–318.

Kwon JE, Kim SH, Cho NH. No ancillary finding is valid to distinguish a primary ovarian hepatoid carcinoma from metastatic hepatocellular carcinoma. Int J Gynecol Cancer. 2006;16:1691–1694.

Wenzel LB, Huang HQ, Armstrong DK, Walker JL, Cella D. Health related quality of life during and after intraperitoneal versus intravenous chemotherapy for optimally debulked ovarian cancer: a gynecologic oncology group study. J Clin Oncol. 2007;25:437–443.


Refbacks

  • There are currently no refbacks.


Copyright (c) 2017 Journal of Pharmaceutical and Biomedical Sciences

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.