Abstract
The stimulating effect of linezolid in 12 infants on neutrophil phagocytosis was established with an increase of phagocytic number, index of phagocytosis and completion index of phagocytosis by 40% or more of the initial values. Vancomycin inhibited phagocytosis of neutrophils in 1 or 2 indicators by 32% or more in six infants. The phagocytic activity of neutrophils in these infants was normalized in the recovery period.
Therefore, the majority of newborns with ventilator-associated pneumonia, linezolid and vancomycin was not affected negatively on the phagocytic activity of blood neutrophils.
Keywords
Full Text:
References
Suhanova LP, Bushmeleva NN, Sorokina ZH. Infant mortality in Russia from positions of validity of its registration: social aspects of population health. 2012;6. 09.01.2013.
The World Health Report. Make every mother and child count. WHO. 2005;229.
Marchulija HM, Kushnareva MV, Dementjeva GM, Shahinian IA, Chernukha MYu, Alekseev GV, et al. The etiology of ventilatorassociated pneumonia in preterm infants. Pediatriya. 2005;3:36–39.
Schelonka RL, Scruggs S, Nichols K, Dimmitt RA, Carlo WA. Sustained reductions in neonatal nosocomial infection rates following a comprehensive infection control intervention. J Perinatol. 2006;26:176–179.
Stoll BJ. The global impact of neonatal infection. Clin Perinatol.1997;24:1–21.
Dietert RR. Developmental immunotoxicology: focus on health risks. Chem Res Toxicol. 2009;22:17–23.
Yushchuk ND, Balmasova IP, Tsarev VN. Antibiotics and anti-infective immunity. Moscow: Practical Medicine: 2012;232.
Kushnareva MV, Dementyeva GM, Gerasimov AYu. The clinical and microbiological efficacy of vancomycin in the combination treatment of newborns with ventilator-associated pneumonia caused by gram-positive cocci. Rossiyskiy vestnik perinatologii i pediatrii. (Russian Bulletin of Perinatology and Pediatrics). 2014;59:71–77.
Kushnareva MV, Gerasimov AYu, Dementyeva GM, Keshishyan ES, Okuneva TS. Comprehensive treatment of ventilator-associated pneumonia in newborns. Rossiyskiy vestnik perinatologii i pediatrii. (Russian Bulletin of Perinatology and Pediatrics).2016;61:92–99.
Kost EA. A Handbook of Clinical Laboratory Methods of research.Moscow: Medicine, 1975:56–57.
Kushnareva MV, Vetrova EV, Kubrin AV. Influence of standard preparations of intravenous immunoglobulins in phagocytic activity of blood neutrophils in preterm neonates with ventilator-associated pneumonia. Vestnik Pediatricheskoyi Pharmakologii I Nutriciologii. 2007;4:51–57.
Zaitseva NV, Lanin DV, Chereshnev VA. The immune and neurotndocrine regulation in the conditions of influence of chemical factors of various origins. Perm; Publishing House “Perm. National Polytechnic University”. 2016;236 .
Zaitseva NI, Trusov PV, Shur PZ, Kir’yanov DA, Chigvintsev VM, Tsinker MY. Methodological approaches to the risk assessment of the impact of diverse environmental factors on the health of the population on the basis of evolutionary models. Analis Riska Zdorovju. 2013;1:3–11.
Dubrovin NM, Dubrovina ES, Rumyantsev AG. Development of the immune system of the fetus. Pediatriya. 2001;4:67–71.
Koval GS, Samsygin SA, Kuznetsova L K. Peculiarities of the immune system of the extremely premature infants with infectious and inflammatory diseases. Rossiyskiy Vestnik Perinatologii I Pediatrii. 1999;2:8–10.
Slobodchikova SV, Shmagel KV, Nikolaeva AM. The Influence of opsonization S. aureus antistaphylococcal immunoglobulin in phagocytosis. Russian Journal of Immunology. 2011;14:266–273.
Refbacks
- There are currently no refbacks.
Copyright (c) 2017 Journal of Pharmaceutical and Biomedical Sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.