Journal of Pharmaceutical and Biomedical Sciences

Intrabony Defect Treated with Platelet-Rich Fibrin: A Case Report

Swyeta Jain Gupta, Amit Gupta, Vivek Gautam, Md. Aamir Ahsan

Abstract


Platelet-rich fibrin (PRF) has gained recommendable importance for predictably obtaining periodontal regeneration. The purpose of this case report is to present clinical and radiographic results of an intrabony periodontal defect treated with PRF. A 36-year-old Indian male presented with an intrabony periodontal defect in relation to 41. The probing pocket depth (PPD) on mesial proximal aspect was 9 mm and clinical attachment level (CAL) was 12 mm. On surgical treatment with bone graft and autologous PRF, one-year follow up revealed a significant reduction in PPD and CAL gain as well as radiographic bone formation, supporting the role of various growth factors present in the PRF in accelerating the soft and hard tissue healing. From the presented case, it can be concluded that PRF is clinically and radiographically efficacious regenerative material in the treatment of a periodontal intrabony defect.

Keywords


intrabony defect, PRF, growth factors

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References


Becker W, Becker BE. Periodontal regeneration: a contemporary re-evaluation. Periodontology. 1999;19:104–114.

Rosen PS, Reynolds MA, Bowers GM. The treatment of intrabony defects with bone grafts. Periodontology. 2000;22:88–103.

Pradeep AR, Shetty SK, Garg G, Pai S. Clinical effectiveness of autologous platelet-rich plasma and peptide-enhanced bone graft in the treatment of intrabony defects. J Periodontol.2009;80:62–71.

Döri F, Kovács V, Arweiler NB, Huszár T, Gera I, Nikolidakis D, et al. Effect of platelet-rich plasma on the healing of intrabony defects treated with an anorganic bovine bone mineral: a pilot study. J Periodontol. 2009;80:1599–1605.

Siciliano VI, Andreuccetti G, Siciliano AI, Blasi A, Sculean A, Salvi GE. Clinical outcomes after treatment of non-contained intrabony defects with enamel matrix derivative or guided tissue regeneration: a 12-month randomized controlled clinical trial. J Periodontol. 2011;82:62–71.

Wu SY, Chen YT, Chen CW, Chi LY, Hsu NY, Hung SL, et al. Comparison of clinical outcomes following guided tissue regeneration treatment with a polylactic acid barrier or a collagen membrane. Int J Periodontics Restorative Dent. 2010;30:173–179.

Carroll RJ, Amoczky SP, Graham S, O’Connell SM. Characterization of autologous growth factors in cascade platelet rich fibrin matrix (PRFM). Edison NJ: Musculoskeletal Transplant

Foundation. 2005.

Choukroun J, Adda F, Schoeffler C, Vervelle A. Une opportunite´ en paro-implantologie: Le PRF. Implantodontie. 2001;42:55–62.

Lekovic V, Milinkovic I, Aleksic Z, Jankovic S, Stankovic P, Kenney EB, et al. Platelet-rich fibrin and bovine porous bone mineral vs.platelet-rich fibrin in the treatment of intrabony periodontal defects. J Periodontal Res. 2012;47:409–417.

Pradeep AR, Sharma A. Autologous platelet-rich fibrin in the treatment of mandibular degree II furcation defects: a randomized clinical trial. J Periodontol. 2011;82:1396–403.

Mazor Z, Horowitz RA, Del Corso M, Prasad HS, Rohrer MD, Dohan Ehrenfest DM. Sinus floor augmentation with simultaneous implant placement using Choukroun’s platelet-rich fibrin as the sole grafting material: a radiologic and histologic study at 6 months. J Periodontol. 2009;80:2056–2064.

Del Corso M, Sammartino G, Dohan Ehrenfest DM. Clinical evaluation of a modified coronally advanced flap alone or in combination with a platelet-rich fibrin membrane for the treatment of adjacent multiple gingival recessions: a 6-month study.J Periodontol. 2009;80:1694–1697.

Sclafani AP. Applications of platelet-rich fibrin matrix in facial plastic surgery. Facial Plast Surg. 2009;25:270–276.

O'Connell SM. Safety issues associated with platelet-rich fibrin method. Oral Surg Oral Med Oral Pathol Oral Radiol Endod.2007;103:587–593.

Blumenthal NM, Alves ME, Al-Huwais, Hofbauer AM, Koperski RD. Defect-determined regenerative options for treating periodontal intrabony defects in baboons. J Periodontol. 2003;74:10–24.

Chang IC, Tsai CH, Chang YC. Platelet-rich fibrin modulates the expression of extracellular signal-regulated protein kinase and osteoprotegerin in human osteoblasts. J Biomed Mater Res A. 2010;95:327–32.

Huang FM, Yang SF, Zhao JH, Chang YC. Platelet-rich fibrin increases proliferation and differentiation of human dental pulp cells. J Endod. 2010;36:1628–32.

Tsai CH, Shen SY, Zhao JH, Chang YC. Platelet-rich fibrin modulates cell proliferation of human periodontally related cells in vitro. J Dent Sci 2009;4:130–5.

Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: platelet-related biologic features. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:e45–e50.

Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part III: leucocyte activation: a new feature for

platelet concentrates? Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:e51–e5.

Diss A, Dohan DM, Mouhyi J, Mahler P. Osteotome sinus floor elevation using Choukroun’s platelet-rich fibrin as grafting material: a 1-year prospective pilot study with microthreaded implants. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;105:572–9.


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