RNA Interference: An Evolutionary Pathway in Periodontal Tissue Engineering

Swyeta Jain Gupta; Amit Gupta; Kaushik Kumar Pandey; Swati Choudhary

RNA Interference: An Evolutionary Pathway in Periodontal Tissue Engineering

Swyeta Jain Gupta, Amit Gupta, Kaushik Kumar Pandey, Swati Choudhary

Abstract

RNA interference (RNAi) is an evolutionary conserved silencing pathway in which the double-stranded RNA is broken down into small interfering RNA (siRNA) with the help of dicer and RNA-induced silencing complex (RISC) complex by a series of steps. Pioneering observations on RNAi were reported in plants, but later on RNAi-related events were described in almost all eukaryotic organisms, including protozoa, flies, nematodes, insects, parasites, and mouse and human cell lines.

Keywords

gene silencing, RNAi, DICER, RISC

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