Evaluation of Troponin T Level in Acute Rheumatic Carditis

Rakesh Kumar Shahi; P. Nigam

Evaluation of Troponin T Level in Acute Rheumatic Carditis

Rakesh Kumar Shahi, P. Nigam

Abstract

Background Acute rheumatic fever (ARF) is more common in children of many developing countries.
Aim The purpose of this study is to test whether it is possible to identify myocardial involvement in cases with rheumatic carditis by the measurement of serum cardiac troponin T (cTnT).

Methods Eighty patients diagnosed as ARF underwent echocardiography and their cTnT serum levels were measured. Patients were divided into groups as Cases and Control with 40 patients in each group.

Results In Cases 57.5% were male and 42.5% were female. All patients complained about joint pain. In 59% of cases troponin T was not detectable. It was detectable in the range of 0.01–0.05 ng/ml in 35% of cases and it was in the range of 0.05–0.1 ng/ml in 7% of cases of endocarditis and pericarditis.

Conclusion Measurement of cTnT may be added to diagnostic accuracy of myocarditis

Keywords

acute rheumatic fever, rheumatic heart disease, Troponin-T

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References

Padmavati S, Gupta V. Reappraisal if Jones criteria: the Indian experience. Z Med J. 1998;101:391–2.

Sharma SD, Gupta RK. Pitfalls in diagnosis of acute rheumatic fever. JK SCIENCE. 2007;9(3):148–9.

Jones criteria: 1992 update. JAMA. 1992;268:2069–73.

Farah CS, Reinach FCR. The troponin complex and regulation of muscles contraction. FASEB J. 1995;9:755–67.

Sallakci N, Akcurin G, Köksoy S, Kardelen F, Uguz A, Coskun M, et al. TNF-alpha G-308A polymorphism is associated with rheumatic fever and correlates with increased TNF-alpha production. J Autoimmun. 2005;25:150–4.

Lloyd Y, Tani MD. Rheumatic fever and rheumatic heart disease. In: Allen HD, Driscoll DJ, Shaddy RE, Feltes TF, (eds): Moss and Adams’ Heart Disease in Infants, Children, and Adolescents: Including the Fetus and Young Adults, 7th ed. Philedelphia: Lipincott Williams and Wilkins; 2008. pp. 1257–75.

Ertug MH, Yilmaz GG, Akçurin G, Kardelen F, Kocabas A, Gumuslu S, et al. Can troponin T levels be useful in the diagnosis of rheumatic carditis? Ann Pediatr Card. 2011;4:156–8.

Trivedi S, Saxena SK, Lalchandani A, Chandra R, Verma CM, Singh RP. Evaluation of Troponin T level in acute rheumatic carditis. Indian J Cardiol. 2013;16(1–2):22–31.

Gupta M, Lent RW, Kaplan EL, Zabriskie JB. Serum cardiac troponin I is acute rheumatic fever. Am J Cardiol. 2002;90 (11):1277–8.

Missov E, Calzolari C, Pau B. Circulating cardiac Troponin I in severe congestive heart failure. Circulation. 1997;96:2953–8.

Alehan D, Ayabakan C, Hallioglu O. Role of serum cardiac Troponin T in the diagnosis of acute rheumatic fever and rheumatic carditis. Heart. 2004;90:689–90.

Oran B, Coban H, Karaaslan S, Atabek E, Gurbilek M, Erkul I. Serum cardiac troponin-I in active rheumatic carditis. Indian J Pediatr. 2001;68(10):943–4.

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