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Exploring the Potential Targets Underlying the Antiviral Effect of Lonicera Japonica in H5N1 Using Network Pharmacology

Huang Huibin

Abstract


Objective: The mechanisms underlying the antiviral effect of Lonicera japonica (LJ) in H5N1 were examined using a systematic network pharmacology approach.

Methods: Targets related to LJ were searched through the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). Proteins related to H5N1 were screened in GeneCards database. The active ingredient-target network and protein-protein interaction (PPI) network were plotted by String database.

Results: Totally 23 active components of LJ were screened out, which corresponded to 386 targets. 162 target genes directly related to H5N1 were screened from the GeneCards database. PPI results indicated that the core proteins were Caspase-8 (CASP8) Albumin (ALB), Caspase-7 (CASP7) Epidermal growth factor receptor (EGFR), Interleukin-6 (IL6), Proliferating cell nuclear antigen (PCNA), Nuclear factor erythroid 2-related factor 2 (NFE2L2) and C-reactive protein (CRP).

Conclusion: Collectively, this study highlights that LJ prescription exerted the effect of antiviral through multiple targets and multiple pathways

Keywords


Lonicera Japonica, C-reactive protein, Antiviral

Full Text:

References


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