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PD-L1 overexpression is Associated with Better Overall Survival in Triple-Negative Breast Cancer: A Meta-Analysis

Qiutong Tan, Enpan Mo, Shaohui Cai, Mingjie Shi, Jun Xu

Abstract


Background Aim we conducted a meta-analysis to investigate the prognostic signi?cance of PD-L1.

Methods: Literature search was performed using the Pubmed, Embase and for relevant articles published.

Results: 18 studies including 5958 patients were included in the pooled analysis. PD-L1 overexpression in breast cancer patients is association with overall survival in overall breast cancer group (HR=1.37, 95% CI: 1.19-2.42) and only TNBC group (HR=0.58, 95%CI: 0.35-0.96), respectively. The results between PD-L1 expression and clinicopathological features suggests PD-L1 is significantly associate with poor tumor cell differentiation, present of vascular invasion, positive HER2 status and more TILs infiltration.

Conclusion: PD-L1 might be a promising biomarker to predict prognosis and helpful in screening candidates for anti-PD-1/PD-L1 therapy.


Keywords


Programmed death ligand 1; Breast cancer; Triple-negative; Prognostic; Meta-analysis

Full Text:

References


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