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Cross-Allergy of Sulfonamide-Containing Drugs in Sulfonamide Allergic Patients: A Literature Review and Case Study

Weile Feng, Jiawen Huang, Yuwen Tang, Zhidong Zhang, Xiaofei Feng, Jianping Zhang

Abstract


The purpose of this study is to find out whether there are broad cross-reactivity between antibacterial and non-antibacterial sulfonamide agents, the method of the study contained two parts, one is literature research mainly from PubMed database by using the MeSH terms (“Drug name” + allergy); (“Drug name” + hypersensitivity); (“Drug name” + cross-allergenicity) and (“Drug name + cross-reactivity), the search drugs included some commonly seen medication such as carbonic anhydrase inhibitor, COX-2 inhibitor, loop diuretic, sulfonylurea, thiazide and certain antiviral drugs; the other parts of this thesis is to conduct a statistical review, we screen out patients who have a previous allergic history of antimicrobial sulfonamides from hospital medical record system during Jan 1st, 2015 to Dec 31th, 2016, we did a descriptive statistics of general patients medical information, analyze the suspect cases which patients present potential allergic reaction after using non-antimicrobial sulfonamides agents. Result of literature research reveal there are no convincing evidences and research to confirm there are bored allergenicity between non-antimicrobial sulfonamides and antimicrobial sulfonamide in the aspects of chemical structure, immunological study, and large scale population study as well; Result of hospital patient’s statistics found out there are only 3 suspected cases that the patients were having adverse effect during their pharmacotherapy from 506 cases. However, we did not found any strong correlation of broad allergenicity between non-antimicrobial sulfonamides and antimicrobial sulfonamides from these suspected cases. Conclusion: There is minimal evidence of cross-reactivity between the antimicrobial sulfonamides and the non-antimicrobial sulfonamides. However, the non-antimicrobial sulfonamides are rarely implicated in hypersensitivity reactions as well, so it is impossible to say with certainty that cross-reactivity does not occur.


Keywords


Sulfonamides, Non-antimicrobial sulfonamides, Cross-allergenicity.

Full Text:

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