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Increased Levels of Serum Cystatin C with Body Mass Index

Pallavi Mahajan, Sodhi KS

Abstract


Obesity is a major causative factor for many metabolic disorders and premature deaths in developing countries. The risk of many diseases like diabetes mellitus, cardiovascular disease, hypertension, hyperlipidemia, and cancers increases many folds in association with obesity. Cystatin C, though considered a renal marker, is associated with obesity irrespective of gender. Cystatin C mRNA is expressed in subcutaneous and omental adipose tissue, at twice higher levels in non-adipose than in adipose cells. The present study was conducted in the Department of Biochemistry, M.M. Institute of Medical Sciences and Research, Mullana, Ambala in which the levels of serum cystatin C were estimated in 100 healthy individuals in the age range of 17 years and above of either sex. All the 100 subjects included in the study were divided further into the suitable groups according to their body mass index and age. It was observed that serum cystatin C levels increase with the increase in BMI in both the age groups. These observations suggest a role for adipose tissue as a contributor to circulating concentration of cystatin C.

Keywords


obesity, cystatin C, body mass index, age

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References


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