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A Meta-Analysis of Efficacy and Safety Evaluation Between Desloratadine Citrate Disodium Versus Loratadine Tablets in Patients with Chronic Urticaria

Lina Zhao, Zhuoru Liang, Yang Wang, Jie Jiang, Tiantian Zhang

Abstract


Objective To summarize the available evidence and assess the efficacy and safety of desloratadine citrate disodium versus loratadine in patients with chronic urticaria (CU).

Methods Databases PubMed (Medline), Web of knowledge, MEDLINE, VIP, Wanfang and CNKI databases were systematically searched for articles. The search results were last updated in June 2017. Quality assessment and data extraction were performed according to the Cochrane Handbook. The meta-analysis was performed using Stata 14.0.

Results Nine randomized controlled trials involving 950 patients were identified. In terms of efficacy, the pooled ORs for the overall responder rate and the complete remission rate were 2.37 (95% CI: 1.77–3.16) and 2.86 (95% CI: 2.25–3.64), respectively. The pooled ORs for 7 days overall responder rate, 14 days overall responder rate, 28 days overall responder rate were 1.92 (95% CI: 1.32–2.79), 3.71 (95% CI: 1.98–6.95),2.64 (95% CI: 1.32–5.27) respectively. The pooled ORs for 7 days complete remission rate, 14 days complete remission rate, 28 days complete remission rate were 2.29 (95% CI: 1.38–3.79), 3.46 (95% CI: 2.28–5.23), 2.78 (95% CI: 1.93–4.01) respectively. In the terms of safety, the pooled OR for adverse events (AEs) was 0.42 (95% CI: 0.24–0.71), with statistical significance. The most common AEs were somnolence, thirst, dizziness, weakness and nausea.

Conclusion Desloratadine citrate disodium is more efficacious and safer than loratadine in patients with CU.


Keywords


chronic urticaria, loratadine, desloratadine citrate disodium, meta-analysis

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