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Dual Role of Endophytic Fungi from the Roots of Terminalia arjuna (Roxb.) Wight & Arn

Thangaraj A, Mujeera Fathima


Plant endophytes constitute different crucial parts of microbial differences. Plant endophytic fungi are an imperative and novel asset of natural bioactive metabolites with their different potential applications in different industries including medicine. This article focuses on the root of Terminalia arjuna, the plant with rich ethnobotanical uses, for the nearness of endophytic organisms and to decide their antibacterial and anticancer potential from its common natural surroundings.
Considering the significance of this plant based on the various research, antibacterial activity was tested against four human pathogenic microorganisms in bioactive metabolites and were subjected to different tests to decide phytochemical constituents. After the screening, MTT was performed in the crude extract. The outcomes demonstrate that the crude extract of fungal endophytes of T. arjuna have both antibacterial effects and anticancer effect when tried in MCF-7 cell line.


Terminalia arjuna (Roxb.) wight & Arn., root endophytes, phytochemicals, MTT, anticancer, antimicrobial

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Sivalokanathan S, Ilayaraja M, Balasubramanian MP. Efficacy of Terminalia arjuna (Roxb.) on N-nitrosodiethylamine induced hepatocellular carcinoma in rats. Indian J Exp Biol. 2005;43:264–267.

Dhiman AK. Ayurvedic Drug Plants. 7th Edition. New Delhi. Daya Publishing House; 2006, pp. 41–43.

Jain V, Poonia A, Agarwal RP, Panwar RB, Kochar DK Misra SN. Effect of Terminalia arjuna in patients of angina pectoris. Ind Med Gaz(New series). 1992;36:56.

Chatterjee A, Pakrashi SC. The Treatise on Indian Medicinal Plants. Vol. III. New Delhi. Publication and Information Directorate. Council of Scientific and Industrial Research; 1994, p. 564.

Hartwell JL. Plants used against cancer (Quarterman Publications, Inc. Lawrene, MA) 1982.

Kapoor LD. CRC Handbook of Ayurvedic Medicinal Plants (CRC Press, Boca Raton, FL) 1990.

Pettit GR, Hoard MS, Doubek DL, Schmidt JM, Pettit RK, Tackett LP, et al. Antineoplastic agents 338. The cancer cell growth inhibitory constituents of Terminalia arjuna (Combretaceae), J Ethanopharmacol. 1996;53:57.

Moulisha B, Kumar GA, PallabKanti H. Anti-leishmanial and anti-cancer activities of a pentacyclictriterpenoid isolated from the leaves of Terminalia arjuna Combretaceae. Trop J Pharm Res. 2010;9:135.

Aneja KR, Sharma C, Joshi R. Antimicrobial activity of Terminalia arjuna Wight & Arn.: an ethnomedicinal plant against pathogens causing ear infection. Braz J Otorhinolaryngol. 2012;78:68–74.

Debnath S, Dey D, Hazra S, Ghosh S, Ray R, Hazra B. Antibacterial and antifungal activity of Terminalia arjuna Wight & Arn. bark against multi-drug resistant clinical isolates. J Coastal Life Medicine. 2013;1:315–321.

Mandal S, Patra A, Samanta A. Analysis of phytochemical profile of Terminalia arjuna bark extract with antioxidative and antimicrobial properties. Asian Pac J Trop Biomed. 2013;3:960–966.

Amalraj A, Gopi S. Medicinal properties of Terminalia arjuna (Roxb.) Wight & Arn.: A review. J Tradit Complement Med. 2017;7:65–78.

Chaudhari M, Mengi S. Evaluation of phytoconstituents of Terminalia arjuna for wound healing activity in rats. Phytother Res. 2006;20:799–805.

Kaur SJ, Grover IS, Kumar S. Modulatory effects of a tannin fraction isolated from Terminalia arjuna on the genotoxicity of mutagens in Salmonella typhimurium. Food ChemToxicol. 2000;38:1113–1119.

Gangadevi V, Muthumary J. Taxol production by Pestalotiopsisterminaliae, an endophytic fungus of Terminalia arjuna (Arjun tree). Biotech and Appl Biochem. 2009;52:9–15.

Kuo PL, Hsu YL, Lin TC, Lin LT, Chang JK, Lin CC. Casuarinin from the Bark of Terminalia arjuna induces apoptosis and cell cycle arrest in human breast adenocarcinoma MCF-7 cells. Planta

Med 2005;71:237–243.

Sivalokanathan S, Vijayababu MR, Balasubramanian MP. Effects of Terminalia arjuna bark extract on apoptosis of human hepatoma cell line HepG2. World J Gastroenterol. 2006;12:1018–1124.

Johannes H, Gabriele B, Barbara S. Isolation procedures for endophytic microorganisms. Springer, Berlin, 2006;p. 299.

Adinarayanan G, Venkatesan M, Saisha V, Bapiraju VVSN, Sujatha P, Premkumar J, et al. Resistoflavine, cytotoxic compound from marine actinomycetes, Streptomyces chibaensis AUBN1/7.

Microbiol Res. 2007;162:322–327.

Tan RX, Zou WX. Endophytes: a rich source of functional metabolites. Nat Prod Rep. 2001;18:448–459.

Harborne JB. Phytochemistry. London: Academic Press; 1993; 89–131.

Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods. 1983;65:55–63.

Pingili D, Anarthe SJ, Raghavendra NM. Evaluation of the polyherbal extract for antioxidant, anticancer and antidiabetic activity. Ann Phytomed 2012;1:39–45.

Saxena M, Faridi U, Mishra R, Gupta MM, Singh D. Cytotoxic agents from Terminalia arjuna. Planta Med. 2007;73:1486–1490.


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