A Study of Intermediate Syndrome in Organo Phosphorus Compound Poisoning in Rural Area

Harshad L. Patel; Abhish H. Bhujbal; V.B. Vikhe

A Study of Intermediate Syndrome in Organo Phosphorus Compound Poisoning in Rural Area

Harshad L. Patel, Abhish H. Bhujbal, V.B. Vikhe

Abstract

Poisoning with organophosphorus compounds is one of the commonest forms of poisoning in our country. Patients with organophosphorus poisoning present with the symptoms and signs of acetylcholine excess, which is called as an acute cholinergic crisis. Type II paralysis or Intermediate syndrome (IS) is one of them. This study of 100 patients has been undertaken in the rural region, where the incidence of poisoning with OPCs is very high. Higher incidence has been reported in age groups (12–40 years). The maximum incidence of intermediate syndrome was seen in poisoning with parathion (75%), followed by dimethoate poisoning with an incidence of 45.3%. The overall incidence of intermediate syndrome in the present study was 37%.Onset of IS was noted to be from 16 h to 96 h. The majority of patients improved within 1 week, while some patients had prolonged IS with duration more than 2 weeks. The range of duration of IS as seen in this study was from 2 days to 18 days.

Keywords

organophosphorus compounds, intermediate syndrome, serum cholinesterase

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