Scaffolds in Periodontal Regeneration

Mitul Mishra; Prachi Mishra; Vaibhao Shambharkar; Amber Raut

Scaffolds in Periodontal Regeneration

Mitul Mishra, Prachi Mishra, Vaibhao Shambharkar, Amber Raut

Abstract

Periodontal tissue engineering requires triad of cells, inductive component and a scaffold on which growth can occur. Previously periodontal treatment was aimed to selectively repopulate the defect site with cell that has capability to regenerate lost tissue by using the concept of guided tissue regeneration. However, this technique is not always possible. Use of scaffolds that can also deliver cells required for regeneration to occur is relatively a newer concept. A biomaterial is defined as a nonviable material used in a medical device, intended to interact with biological systems. For a device to be effective, it has to meet certain criteria based on organ and tissue properties and specific goals. Every material available in market has its own advantages and disadvantages. This review will mainly focus on the devices along with the advancement taking place related to cell delivery system.

Keywords

regeneration, tissue engineering, scaffold, cell delivery system

Full Text:

References

Narem R, Sambanis A. Tissue engineering: from biology to biological structures. Tissue Eng. 1995;1:3–13.

Slavkin HC, Bartold PM. Challenges and potential in tissue engineering. Periodontol 2000. 2006;41:9–15.

Bartold PM, McCulloch CAG, Narayanan AS, Pitaru S. Tissue engineering: a new paradigm for periodontal regeneration based on molecular and cell biology. Periodontol 2000. 2000;24:253–69.

Malekzeh R, Hollinger JO, Buck D, Adams DF, McAllister BS. Isolation of human osteoblast-like cells and in vitro amplification for tissue engineering. J Periodontol. 1998;69:1256–62.

Lang H, Schüler N, Nolden R. Attachment formation following replantation of cultured cells into periodontal defects. J Dent Res. 1998;77:393–405.

Baum B, Mooney DJ. The impact of tissue engineering on dentistry. JADA. 2000;131:309–18.

Polimeni G, Xiropaidis AV, Wikesjö UM. Biology and principles of periodontal wound healing/regeneration. Periodontology 2000. 2006;41:30–47.

Bartold PM, Xiao Y, Lyngstaadas SP, Paine ML, Snead ML. Principles and applications of cell delivery systems for periodontal regeneration. Periodontology 2000. 2006;41:123–35.

Dong J, Uemura T, Shiraski Y Tateishi T. Promotion of bone formation using highly pure porous beta-TCP combined with mesenchymal stem cells. Biomaterials. 2002;23:4493–502.

Gronthos S, Chen S, Wang CY, Robey PG, Shi S. Telomerase accelerates osteogenesis of bone marrow stromal stem cells by upregulation of CBFA1, osterix, and osteocalcin. J Bone Miner Res. 2003;18:716–22.

Jansen JA, von Recum AF, van der Waerden JP, de Groot K. Soft tissue response to different types of sintered metal fibre-web materials. Biomaterials. 1992;13:959–68.

Walboomers XF, Habraken WJ, Feddes B, Winter LC, Bumgardner JD, Jansen JA. Stretch-mediated responses of osteoblast-like cells cultured on titanium-coated substrates in vitro. J Biomed Mater Res. 2004;69A:131–9.

Van den Dolder J, Spauwen PH, Jansen JA. Evaluation of various seeding techniques for culturing osteogenic cells on titanium fiber mesh. Tissue Eng. 2003a;9:315–25.

Vehof JW, Spauwen PH, Jansen JA. Bone formation in calciumphosphate-coated titanium mesh. Biomaterials. 2000;21:2003–9.

Yang S, Leong K-F, Du Z, Chua C-K. The design of scaffolds for use in tissue engineering. Part 1. Traditional factors. Tissue Eng.2001;7:679–89.

Kim B-S, Mooney DJ. Development of biocompatible synthetic extracellular matrices for tissue engineering. Trends Biotechnol. 1998;16:224–30.

Toole BP. Hyaluronan in morphogenesis. J Intern Med.1997;242:35–40.

Ma L, Gao C, Mao Z, Zhou J, Shen J, Hu X, Han C. Collagen/chitosan porous scaffolds with improved biostability for skin tissue engineering. Biomaterials. 2003;24:4833–41.

Xiao Y, Qian H, Young WG, Bartold PM. Tissue engineering for one regeneration using differentiated alveolar bone cells in collagen scaffolds. Tissue Eng. 2003;9:1167–77.

Drury JL, Mooney DJ. Hydrogels for tissue engineering: scaffold design variables and applications. Biomaterials. 2003;24:4337–51.

Xiao Y, Haase H, Young WG, Bartold PM. Development and transplantation of a mineralized matrix formed by osteoblasts in vitro for bone regeneration. Cell Transplant. 2004;13:15–25.

Scantlebury TV. 1982–1992: a decade of technology development for guided tissue regeneration. J Periodontol. 1993;64:1129–37.

Whang K, Healy KE, Elenz DR, Nam EK, Tsai DC, Thomas CH, et al. Engineering bone regeneration with bioresorbable scaffolds with novel microarchitecture. Tissue Eng. 1999;5:35–51.

Kim B-S, Mooney DJ. Development of biocompatible synthetic extracellular matrices for tissue engineering. Trends Biotechnol.1998;16:224–30.

Rihova B. Immunocompatability and biocompatability of cell delivery systems. Adv Drug Deliv Rev. 2000;42:65–80.

Anusaksathien O, Jin Q, Zhao M, Somerman MJ, Giannobile WV. Effect of sustained gene delivery of platelet-derived growth factor or its antagonist (PDGF-1308) on tissue-engineered cementum. J Periodontol. 2004;75:429–40.

Zhao, M, Jin Q, Berry JE, Nociti FH, Giannobile WV, Somerman MJ. Cementoblast delivery for periodontal tissue engineering. J Periodontol. 2004;75:154–61.

Seo B-M, Miura M, Gronthos S, Bartold PM, Batouli S, Brahim J, et al. Multipotent stem cells from human periodontal ligament.Lancet. 2004;364:149–55.

Xiao Y, Qian H, Young WG, Bartold PM. Tissue engineering for bone regeneration using differentiated alveolar bone cells in collagen scaffolds. Tissue Eng. 2003;9:1167–77.

Tabata Y. Tissue regeneration based on growth factor release. Tissue Eng. 2003;9(Suppl. 1):S1–S15.

Taka Nakahara. A review of new developments in tissue engineering therapy for periodontitis. Dent Clin N Am. 2006;50:265–76.

Ramseier CA, Abramson ZR, Jin Q, Giannobile WV. Gene therapeutics for periodontal regenerative medicine. Dent Clin N Am.2006;50:245–63.

Kong LX, Peng, Li SD, Bartold PM. Nanotechnology and its role in the management of periodontal diseases. Periodontology 2000. 2006;40:184–96.

Refbacks

There are currently no refbacks.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Journal of Pharmaceutical and Biomedical Sciences