Abstract
Background and Objectives There is limited information on the efficacy and safety of compound left acetylene progesterone tablets (LNG/EE 100/20 ?g) in contraception.
To evaluate the efficacy and safety of LNG/EE 100/20 ?g for contraception.
Method We searched the medical databases including Pubmed, Web of science, EMbase and Cochrane library through computer; extracted and evaluated the data then performed the meta-analysis by using Review Manager 5.3 software.
Result A total of seven randomised controlled trials including 1786 subjects were recruited for meta-analysis. Compared with other compound oral contraceptives, LNG/EE 100/20 ?g showed no significant differences in contraception efficacy [OR = 1.08, 95% CI (0.29, 4.04), P = 0.91] and safety [OR = 0.99, 95% CI (0.81, 1.21), P = 0.92]; however, it is better than the other compound oral contraceptives on cycle control efficacy of short cycle [OR = 1.75, 95% CI (1.28, 2.38), P = 0.0004].
Conclusion LNG/EE 100/20 ?g were better than the other compound oral contraceptives on cycle control of short cycle, and showed no significant differences in the efficacy and safety.
Keywords
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