The Ameliorative Effects of CE (A Chicken Extract) on Learning and Memory Function of Restraint-Stressed Mice

Wen-Shan Huang; Yi-Fang Li; Huan Chen; Ting-Mei Wang; Hiroshi Kurihara; Rong-Rong He

The Ameliorative Effects of CE (A Chicken Extract) on Learning and Memory Function of Restraint-Stressed Mice

Wen-Shan Huang, Yi-Fang Li, Huan Chen, Ting-Mei Wang, Hiroshi Kurihara, Rong-Rong He

Abstract

In this study, we studied the effects of Chicken Essence (CE) on learning and memory function of restraint-stressed mice. Male Kunming mice of 7-week-old were randomly divided into five groups as follows: normal control, restraint stress control, low dosage of CE (12 ml/kg/d, CE-L) and high dosage of CE (24 ml/kg/d, CE-H). The normal control group and restrain stress control group received water only. On the 14th day of administration, all mice were conducted to step through training, and physically restrained in a 50 ml restrained tube with holes for 18 h except for normal control mice. All mice were conducted to step through testing, 1 day after restraint stress. All animals were anesthetized, their brains and blood were obtained. We determined the neuron protective transmitters, dopamine hydrochloride and norepinephrine level in brain and plasma via ESA–HPLC. The results showed that the administration of CE could improve the impaired function of learning and memory. Furthermore, it also recovered the changed levels of neurotransmitters in brain or plasma in restraint-stressed mice.

Keywords

learning and memory; restraint stress; stress hormone

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