Effects of Chicken Extract on the Serotonergic System of Mice Loaded with Restraint Stress

Huan Chen; Yi-Fang Li; Chong Jie; Hiroshi Kurihara; Rong-Rong He

Effects of Chicken Extract on the Serotonergic System of Mice Loaded with Restraint Stress

Huan Chen, Yi-Fang Li, Chong Jie, Hiroshi Kurihara, Rong-Rong He

Abstract

Chicken extract (CE), which is composed of water-soluble substances extracted from chicken by double boiling, could enhance mental efficiency and are helpful to the recovery from postpartum sickness and mental fatigue. But, little information is available regarding its underlying mechanisms. 5-hydroxytryptamine (5-HT), as a central neurotransmitter, involves in various functional changes of brain. In our study, we studied the effects of CE on 5-HT level in restraint-stressed mice. Male Kunming mice were randomly divided into four groups as follows: normal, restraint stress, restraint stress + 12 mL/kg/d CE (CE-L), restraint stress + 24 mL/kg/d CE (CE-H). On the 14th day of administration, all mice were physically restrained in a 50 mL polypropylene centrifuge tube with holes for 18 h except for normal group. All mice were diethyl ether-anesthetised, 1 day after restraint stress
and their brains were obtained for reverse transcription polymerase chain reaction. The levels of 5-HT in plasma, cerebral cortex and hippocampus were also determined by high performance liquid chromatography with an electrochemical detection. The results showed that CE could recover the changed levels of 5-HT in brain or plasma induced by restraint stress, the mechanism may be related to its modulation on tryptophan hydroxylase activity

Keywords

chicken extract; 5-hydroxytryptamine (5-HT); restraint stress

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