Abstract
Background The change in epidemiology and antifungal susceptibility has generated interest among clinical microbiologists in the identification of Candida up to species level along with antifungal susceptibility patterns.
Objectives This study was undertaken to investigate the prevalence of Candida spp and its antifungal susceptibility from the various clinical samples.
Materials and Methods Total of 317 clinical samples from various suspected fungal infections were received in the Department of Microbiology to investigate suspected Candidal infections. Isolation, identification and antifungal susceptibility were done by
standard conventional methods.
Results A total of 104 non-duplicate Candida species were isolated, out of which 37 (35.6%) were C. albicans and 67 (64.4) were non-C. albicans, and the remaining were C. tropicalis 35 (33.7%), C. glabrata 18 (17.3%) and C. parapsilosis 6 (5.8%). Maximum isolates were from sputum as well as body fluids followed by pus, tissue and urine. Antifungal susceptibility showed higher degree of resistance to Fluconazole (4%), followed by Clotrimazole (2%) and lower degree to Amphotericin B (1%). All isolates were susceptible to Ketoconazole, Voriconazole and Nystatin.
Conclusion An increase in the infections was caused by non-candida albicans species. Candida species identification and antifungal susceptibility are important for the treatment especially for those who hospitalise with serious underlying disease.
Keywords
References
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